Non-linear analysis of a model for yeast cell communication

Calvez, Vincent; Lepoutre, Thomas; Meunier, Nicolas; Muller, Nicolas

ESAIM: Mathematical Modelling and Numerical Analysis , Tome 54 (2020) no. 2, pp. 619-648.

Suite au passage du modèle économique de la revue en S20, le texte intégral des articles des années 2019 et 2020 est accessible uniquement sur le site de l'éditeur et est réservé aux abonnés.

We study the non-linear stability of a coupled system of two non-linear transport-diffusion equations set in two opposite half-lines. This system describes some aspects of yeast pairwise cellular communication, through the concentration of some protein in the cell bulk and at the cell boundary. We show that it is of bistable type, provided that the intensity of active molecular transport is large enough. We prove the non-linear stability of the most concentrated steady state, for large initial data, by entropy and comparison techniques. For small initial data we prove the self-similar decay of the molecular concentration towards zero. Informally speaking, the rise of a dialog between yeast cells requires enough active molecular transport in this model. Besides, if the cells do not invest enough in the communication with their partner, they do not respond to each other; but a sufficient initial input from each cell in the dialog leads to the establishment of a stable activated state in both cells.

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