Combinatorial optimization in DNA mapping - A computational thread of the simplified partial digest problem
RAIRO - Operations Research - Recherche Opérationnelle, Volume 39 (2005) no. 4, p. 227-241

In the paper, the problem of the genome mapping of DNA molecules, is presented. In particular, the new approach - the Simplified Partial Digest Problem (SPDP), is analyzed. This approach, although easy in laboratory implementation and robust with respect to measurement errors, when formulated in terms of a combinatorial search problem, is proved to be strongly NP-hard for the general error-free case. For a subproblem of the SPDP, a simple O(n log n)-time algorithm is given, where n is a number of restriction sites.

Keywords: combinatorial optimization, DNA restriction mapping, partial digest, computational complexity
     author = {Blazewicz, Jacek and Kasprzak, Marta},
     title = {Combinatorial optimization in DNA mapping - A computational thread of the simplified partial digest problem},
     journal = {RAIRO - Operations Research - Recherche Op\'erationnelle},
     publisher = {EDP-Sciences},
     volume = {39},
     number = {4},
     year = {2005},
     pages = {227-241},
     doi = {10.1051/ro:2006007},
     zbl = {pre05233849},
     language = {en},
     url = {}
Blazewicz, Jacek; Kasprzak, Marta. Combinatorial optimization in DNA mapping - A computational thread of the simplified partial digest problem. RAIRO - Operations Research - Recherche Opérationnelle, Volume 39 (2005) no. 4, pp. 227-241. doi : 10.1051/ro:2006007.

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